Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis.
Abstract
OBJECTIVE
This study aims to evaluate the association between patient sex and discharge disposition as well as inpatient mortality following elective primary total hip arthroplasty (THA) for osteoarthritis (OA) in the United States.
METHODS
This study used the 2016-2019 US National Inpatient Sample, a nationally representative dataset, to conduct a cross-sectional study. Adjusted odds ratios and 95% confidence intervals (CIs) were calculated to assess the association of sex with discharge disposition and in-hospital mortality after elective primary THA for OA, adjusting for demographics, comorbidity, social determinants of health (income, insurance payer), hospital characteristics (bed size, location/teaching status, region, control), and postprocedural complications (for mortality and discharge disposition).
RESULTS
There were 1,507,085 elective primary THA hospitalizations for OA in the 2016-2019 National Inpatient Sample data. The mean age was 65.6 years, 55.7% were female, and the mean Deyo-Charlson comorbidity index score was 0.6. In multivariable-adjusted analysis, compared with male sex, female sex was associated with nonhome discharge, but not with in-hospital mortality following elective THA for OA; the adjusted odds ratios were 1.27 (95% CI, 1.25-1.29; p < 0.001) and 0.72 (95% CI, 0.46-1.13; p = 0.15), respectively.
CONCLUSIONS
Female sex was a risk factor for nonhome discharge, but not in-hospital mortality after elective primary THA for OA. It remains to be seen whether better patient health optimization with clinical pathways and targeted interventions in females undergoing elective primary THA can reduce the complication rate.
Links & Identifiers
10.1097/RHU.0000000000002193 Open → 39947834 View on PubMed → MeSH Terms
Keywords
Citation
Chandrupatla SR, Singh JA. Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis.. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2025;31(4):134-141. doi: 10.1097/RHU.0000000000002193
BibTeX
@article{sr2025associationofpatient,
title = {Association of Patient Sex With Inpatient Mortality After Elective Primary Total Hip Arthroplasty for Osteoarthritis.},
author = {Chandrupatla SR and Singh JA},
journal = {Journal of clinical rheumatology : practical reports on rheumatic \& musculoskeletal diseases},
year = {2025},
volume = {31},
number = {4},
pages = {134-141},
doi = {10.1097/RHU.0000000000002193},
pmid = {39947834},
url = {https://doi.org/10.1097/RHU.0000000000002193}
}